Giovanni Corso

Bio:EDUCATION, TRAINING, POSTGRADUATE TRAINING

• 15 October 2002. Graduation cum laude in Medicine and Surgery (six years), University of Siena, Siena Italy. Thesis title: Multiple primary gastric neoplasms: clinico-statistical considerations.

• 9 February 2009. Graduation cum laude and surgical training in General and Emergency Surgery University of Siena (six years); Policlinico S. Maria alle Scotte, Departments of General Surgery and Surgical Oncology – Siena (Italy). Thesis title: The role of prophylactic total gastrectomy in CDH1 gene germline mutation carriers.

• 20 March 2012. PhD graduation cum laude at the University of Porto, Portugal, in Medicine and Molecular Oncology. Thesis title: Searching for novel diagnostic-prognostic biomarkers in gastric cancer.

PRIZE AND AWARD

Gastrointestinal Cancers Symposium Merit Award (ASCO-American Society of Clinical Oncology), San Francisco (USA), January 2011. “Oncogenic mutations in MAPK cascade as novel molecular biomarkers for treatment of gastric cancer patients with EGFR inhibitors”. (2011 Gastrointestinal Cancers Symposium Merit Award Winner).

REVIEWER IN PEER-REVIEWED JOURNAL, EDITORIAL

Reviewer of:
• “Familial Cancer” journal. ISSN: 1573-7292;
• “European Journal of Surgical Oncology”. ISSN: 0748-7983;
• “Journal of Cellular and Molecular Medicine”. ISSN: 1582-4934;
• “Journal of Surgical Oncology”. ISSN: 1096-9098;
• "African Journal of Biotechnology". ISSN: 1684-5315;
• "BMC Cancer". ISSN: 1471-2407.
• “European Journal of Human Genetics”. ISSN: 1018-4813
• “Cancer”. ISSN: 1097-0142
• Annals of Oncology
• European Journal of Cancer Prevention

Associate Editor of :
• BMC Cancer” journal. ISSN: 1471-2407.
• Edorium Journal
• OA Cancer Journal

RESEARCH ACTIVITY

• Hereditary Gastric Cancer and CDH1 gene mutations.
• Familial data collection in oncological patients and familial risk evaluation.
• Microsatellite Instability role in gastric and colon cancers.
• EGFR inhibitors in gastric cancer and targeted therapies.
• Polymorphism correlations with cancer risk development.
• Molecular biomarkers in gastric cancer.
• KRAS, BRAF, PIK3CA, MLK3 and MAPK/PI3K pathway in gastric and colo-rectal cancers.
• Genomic DNA methylation profiles, promoter inactivation.
• Stem cells in breast cancer
• Cell line culture
• Breast cancer stem cells and mammosphere culture

PARTICIPATION IN RESEARCH PROJECTS

1. Gastric carcinoma and Helicobacter Pylori infection: role of bacterial infection and host genetic polymorphism (Programmi di Ricerca Scientifica di Rilevante Interesse Nazionale grant 2004)
2. Clinical implication of E-cadherin gene in gastric carcinoma predisposition and genesis in an high incidence zone (Piano Ateneo della Ricerca grant 2004)
3. Correlation between mammaglobin tissue expressions and tumoral phenotypes in breast cancer and its prognostic role (Piano Ateneo della Ricerca grant 2005)
4. Genetic and inherited factors in gastric carcinoma (Programmi di Ricerca Scientifica di Rilevante Interesse Nazionale grant 2005-2005064071_004)
5. Identification of predictive markers of therapeutic response and expression of circulating nucleic acids in gastric cancer patients. From clinical overview to translational research (Piano Ateneo della Ricerca grant 2006).
6. Gene expression profile and therapeutic implication in gastric cancer. From the clinical overview to the translational research (Istituto Toscano Tumori grant 2007)
7. Exploring the role of E-Cadherin-HER interaction in the search of molecular biomarkers for the clinical management of gastric cancer patients (Fundação para a Ciência e a Tecnologia grant 2007-PIC/IC/82923/2007) [Ref. publication list n° 28, 37, 38, 43].
8. Biomarkers in gastric cancer (Fundação para a Ciência e a Tecnologia grant 2007-SFRH/BD/40090/2007)
9. Understanding how câncer stem cells drive breast câncer growth and how to exploit the mas its Achille’s heal (Grant 5x1000 AIRC 2013).

EXTENDED PUBLICATIONS IN PEER-REVIEWER PAPERS

Author/co-author of 51 publications in national and international peer-review papers and of 40 congress abstracts, in national and international congress (please find in attachment the detailed publication list). Author/co-authors of three chapter book.

1. De Marco G, Roviello F, Marrelli D, De Stefano A, Neri A, Rossi S, Giovanni Corso, Rampone B, Nastri G and Pinto E. A clinical case of duodenal gastrointestinal stromal tumor with a peculiarity in the surgical approach. Tumori 91:261-263; 2005.
2. Rampone B, Roviello F, Marrelli D, De Stefano A, Neri A, Mariani F, De Marco G, Giovanni Corso, Cerullo G, Caruso S and Pinto E. Peritoneal carcinomatosis due to ocular melanoma. Minerva Chirurgica 61:72-73; 2006.
3. Roviello F, Rossi S, Marrelli D, De Manzoni G, Pedrazzani C, Morgagni P, Giovanni Corso and Pinto E. Perforated gastric carcinoma: a report of 10 cases and review of the literature. World Journal of Surgical Oncology. 4:19; 2006.
4. Rampone B, Roviello F, Marrelli D, De Marco G, Rossi G, Giovanni Corso, Cerullo G and Pinto E. Late recurrence of malignant melanoma presenting as small bowel intussusception. Digestive Diseases and Sciences. 51:1047-8; 2006.
5. Neri A, Marrelli D, Roviello F, De Marco G, Mariani F, De Stefano A, Megha T, Caruso S, Giovanni Corso, Coppa T and Pinto E. Bcl-2 expression correlates with lymphovascular invasion and long-term prognosis in breast cancer. Breast Cancer Research and Treatment. 99:77-83; 2006.
6. Roviello F, Rossi S, Marrelli D, Pedrazzani C, Giovanni Corso, Vindigni C, Morgagni P, Saragoni L, De Manzoni G and Tomezzoli A. Number of lymph node metastases and its prognostic significance in early gastric cancer: a multicentric italian study. Journal of Surgical Oncology. 94:275-280; 2006.
7. Marrelli D, Pedrazzani C, Neri A, Giovanni Corso, De Stefano A, Pinto E and Roviello F. Complications after extended (D2) and superextended (D3) lymphadenectomy for gastric cancer: analysis of potential risk factors. Annals of Surgical Oncology. 14:25-33; 2007.
8. Pedrazzani C, De Manzoni G, Marrelli D, Giacopuzzi S, Giovanni Corso, Bernini M and Roviello F. Nodal staging of gastro-esophageal junction adenocarcinoma. Proposal of a specific staging system. Annals of Surgical Oncology. 14:299-305; 2007.
9. Neri A, Rossi S, Marrelli D, De Stefano A, Mariani F, De Marco G, Caruso S, Giovanni Corso, Cioppa T, Pinto E and Roviello F. Breast cancer local recurrence: risk factors and prognostic relevance of early time to recurrence. World Journal of Surgery. 31:36-45; 2007.
10. Roviello F, Giovanni Corso, Pedrazzani C, Marrelli D, De Falco G, Berardi A, Garosi L, Suriano G, Vindigni C, De Stefano A, Leoncini L, Seruca R and Pinto E. Hereditary diffuse gastric cancer: description of the first germline mutation in an Italian family. European Journal of Surgical Oncology. 33:448-451; 2007.
11. Pedrazzani C, Marrelli D, Rampone B, De Stefano A, Giovanni Corso, Fotia G, Pinto E and Roviello F. Postoperative complications and functional results after subtotal gastrectomy with Billroth II reconstruction for primary gastric cancer. Digestive Disease and Science. 52:1757-1763; 2007.
12. Giovanni Corso, Roviello F, Paredes J, Pedrazzani C, Novais M, Correia J, Marrelli D, Cirnes L, Seruca R, Oliveira C and Suriano G. Characterization of the P373L E-Cadherin germline missense mutation and implication for clinical management. European Journal of Surgical Oncology. 33:1061-7; 2007.
13. Pedrazzani C, de Manzoni G, Marrelli D, Giacopuzzi S, Giovanni Corso, Minicozzi AM, Rampone B and Roviello F. Lymph node involvement in advanced gastroesophageal junction adenocarcinoma. The Journal of Thoracic and Cardiovascular Surgery. 134:378-85; 2007.
14. Pedrazzani C, Giovanni Corso, Marrelli D and Roviello F. E-Cadherin and hereditary diffuse gastric cancer. Surgery. 142:645-57; 2007.
15. Roviello F, Giovanni Corso, Pedrazzani C, Marrelli D, De Falco G, Berardi A, Garosi L, Suriano G, Vindigni C, De Stefano A, Leoncini L, Seruca R and Pinto E. Familial history of gastric cancer in an high incidence Italian area. Oncology. 72:243-247; 2007.
16. Pedrazzani C, Caruso S, Giovanni Corso, Marrelli D, Neri A, Berardi A, Roviello F. Influence of age on solubile E-cadherin serum levels prevents its utilità as disease marker in gastric cancer patients. Scandinavian Journal of Gastroenterology. 43:765-766; 2008.
17. Neri A, Marrelli D, Caruso C, Pedrazzani C, De Stefano A, Mariani F, Megha T, De Marco G, Giovanni Corso, Pinto E, Roviello F. Prognostic relevance of proliferative activity evaluated by Mib-1 immunostaining in node negative breast cancer. European Journal of Surgical Oncology. 34:1299-1303; 2008.
18. Giovanni Corso, Berardi A, Marrelli D, Pedrazzani C, Garosi L, Pinto E, Roviello F. CDH1 C-160A promoter polymorphism and gastric cancer risk. European Journal of Cancer Prevention. 18:46-49; 2009.
19. Giovanni Corso, Pedrazzani C, Marrelli D, Pascale V, Pinto E, Roviello F. Microsatellite instability at multiple loci shows a strong correlation with better long-term survival in advanced gastric cancer cases. Archives of Surgery. 144:722-777; 2009.
20. Canedo P, Giovanni Corso, Pereira F, Lunet N, Suriano G, Figueiredo C, Pedrazzani C, Moreira H, Barros H, Carneiro F, Seruca R, Roviello F, Machado JC. The interferon gamma receptor 1 (IFNGR1) -56C/T gene polymorphism is associated with increased risk of early gastric carcinoma. Gut. 57:1504-1508; 2008.
21. Roviello F, Pedrazzani C, Marrelli D, Neri A, Caruso S, Rampone B, Giovanni Corso, De Stefano A, Pinto E. Il trattamento chirurgico del carcinoma gastrico. Chirurgia Italiana. 3:367-379; 2008.
22. Pedrazzani C, Giovanni Corso, Velho S, Leite M, Pascale V, Bettarini F, Marrelli D, Seruca R, Roviello F. Evidence of tumor microsatellite instability in gastric cancer with familial aggregation. Familial Cancer. 8:215-20; 2009.
23. Giovanni Corso, Pedrazzani C, Marrelli D, Pinto E, Roviello F. Familial gastric cancer and Li-Fraumeni syndrome. European Journal of Cancer Care. 19:377-381; 2010.
24. Marrelli D, Pedrazzani C, Berardi A, Giovanni Corso, Neri A, Garosi L, Vindigni C, Santucci A, Figura N, Roviello F. Negative Helicobacter pylori status is associated with poor prognosis in gastric cancer patients. Cancer. 115:2071-2080; 2009.
25. Oliveira C, Senz J, Kaurah P, Pinheiro H, Sanges R, Haegert A, Giovanni Corso, Schouten J, Fitzgerald R, Vogelsang H, Keller G, Dwerryhouse S, Grimmer D, Chin S-F, Yang H-K, Jackson C-E, Seruca R, Roviello F, Stupka E, Caldas C, Huntsman D. Germline CDH1 Deletions in Hereditary Diffuse Gastric Cancer Families. Human Molecular Genetics. 18:1545-1555; 2009.
26. Marrelli D, Pedrazzani C, Giovanni Corso, Neri A, Di Martino M, Pinto E, Roviello F. Different Pathological Features and Prognosis in Gastric Cancer Patients Coming From High-Risk and Low-Risk Areas of Italy. Annals of Surgery. 250:43-50; 2009.
27. MacConaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, Davis M, Yao K, Hanna M, Mondal C, Luongo L, Emery CM, Baker AC, Philips J, Goff DJ, Fiorentino M, Rubin MA, Polyak K, Chan J, Wang Y, Fletcher JA, Santagata S, Giovanni Corso, Roviello F, Shivdasani R, Kieran MW, Ligon KL, Stiles CD, Hahn WC, Meyerson ML, Garraway LA. Profiling critical cancer gene mutations in clinical tumor samples. PlosOne. 4:e7887; 2009.
28. Giovanni Corso, Marrelli D, Pedrazzani C, Machado JC, Mancini S, Seruca R, Roviello F. Gastric Cardia Carcinoma is Associated with the Promoter -77T>C Gene Polymorphism of X-Ray Cross-Complementing Group 1 (XRCC1). Journal of Gastrointestinal Surgery. 13:2233-2238; 2009.
29. Pedrazzani C, Sivins A, Ancans G, Marrelli D, Giovanni Corso, Krumins V, Roviello F, Leja M. Ratio between metastatic and examined lymph nodes (N ratio) may have low clinical utility in gastric cancer patients treated by limited lymphadenectomy: results from a single-center experience of 526 patients. World Journal of Surgery. 34:85-91; 2010.
30. Roviello F, Pedrazzani C, Marrelli D, Di Leo A, Caruso S, Giacopuzzi S, Giovanni Corso, de Manzoni G. Super-extended (D3) lymphadenectomy in advanced gastric cancer. European Journal of Surgical Oncology. 36:439-446; 2010.
31. Leite M, Giovanni Corso, Sousa S, Milanezi F, Afonso LP, Henrique R, Manuel Soares J, Castedo S, Carneiro F, Roviello F, Oliveira C, Seruca R. MSI phenotype and MMR alterations in familial and sporadic gastric cancer. International Journal of Cancer 128:1606-1613; 2011.
32. Caruso S, Marrelli D, Pedrazzani C, Neri A, Mazzei MA, Onorati M, Giovanni Corso, Cerullo G, Roviello F. A rare case of primary small bowel adenocarcinoma with intussusception. Tumori. 96:355-357; 2010.
33. Fitzgerald RC, Hardwick R, Huntsman D, Carneiro F, Guilford P, Blair V, Chung DC, Norton J, Ragunath K, Van Krieken JH, Dwerryhouse S, Caldas C; International Gastric Cancer Linkage Consortium. Collaboratos: Allum W, Attwood S, Blair V, Bradshaw N, Brewer C, Caldas C, Carneiro F, Cats A, Charlton A, Chung DC, Cole T, Giovanni Corso, Crabtree J, Dorkins H, Downing S, Dunn J, Dwerryhouse S, Fairclough P, Fitzgerald R, Going J, Grimes S, Guilford P, Hallissey M, Hallowell N, Hardwick R, Hoogerbrugge N, Huiart L, Huntsman D, Keller G, Kershaw A, Kumar A, Lovat L, McColl K, McKee S, Norton J, O'Donovan M, Oliveira C, Olschwang S, Patel BP, Paterson J, Pedrazzani C, Pharoah P, Ragunath K, Roviello F, Save V, Sengupta S, Seruca R, Shah MA, Stein H, Van Krieken N, van Krieken JH, Wallis M, Wirtzfeld D. Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research. Journal of Medical Genetics. 47:436-444; 2010.
34. Roviello F, Pinto E, Giovanni Corso, Pedrazzani C, Caruso S, Filippeschi M, Petrioli R, Marsili S, Mazzei MA, Marrelli D. Safety and potential benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in peritoneal carcinomatosis from primary or recurrent ovarian cancer. Journal of Surgical Oncology 102:663-70; 2010.
35. Velho S, Giovanni Corso, Oliveira C, Seruca R. KRAS signaling pathway alterations in microsatellite unstable gastrointestinal cancers. Advances in cancer research 109:123-143; 2010.
36. Pedrazzani C, Cerullo G, Marrelli D, Fernandes E, Carlucci F, Giovanni Corso, Bettarini F, De Stefano A, Roviello F. Is circulating D-dimer level a better prognostic indicator than CEA in resectable colorectal cancer? Our experience on 199 cases. The International Journal of Biological Markers 25:171-176; 2010.
37. Giovanni Corso, Velho S, Paredes J, Pedrazzani C, Martins D, Milanezi F, Pascale V, Vindigni C, Pinheiro H, Leite M, Marrelli D, Sousa S, Carneiro F, Oliveira C, Roviello F, Seruca R. Oncogenic mutations in gastric cancer with microsatellite instability. European Journal of Cancer 47:443-451; 2011.
38. Giovanni Corso, Pedrazzani C, Pinheiro H, Fernandes E, Marrelli D, Rinnovati A, Pascale V, Seruca R, Oliveira C, Roviello F. E-cadherin genetic screening and clinico-pathologic characteristics of Early Onset Gastric Cancer. European Journal of Cancer 47:631-639; 2011.
39. Giovanni Corso, Marrelli D, Roviello F. Familial gastric cancer: update for practice management. Familial Cancer, 10:391-396;2011.
40. Marrelli D, Mazzei MA, Pedrazzani C, Di Martino M, Vindigni C, Giovanni Corso, Morelli E, Volterrani L, Roviello F. High Accuracy of Multislices Computed Tomography (MSCT) for Para-Aortic Lymph Node Metastases from Gastric Cancer: A Prospective Single-Center Study. Annals of Surgical Oncology, 18:2265-2272;2011.
41. Kalimutho M, Di Cecilia S, Del Vecchio Blanco G, Roviello F, Sileri P, Cretella M, Formosa A, Giovanni Corso, Marrelli D, Pallone F, Federici G, Bernardini S. Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer. British Journal of Cancer 104:1770-1778; 2011.
42. Caldeira J, Simões-Correia J, Paredes J, Pinto MT, Sousa S, Giovanni Corso, Marrelli D, Roviello F, Pereira PS, Weil D, Oliveira C, Casares F, Seruca R. CPEB1, a novel gene silenced in gastric cancer: a Drosophila approach. Gut 2011, in press.
43. Giovanni Corso, Marrelli D, Pascale V, Vindigni C, Roviello F. Frequency of CDH1 germline mutations in gastric carcinoma coming from high- and low-risk areas: metanalysis and systematic review of the literature. BMC Cancer, 2012 in press.
44. Giovanni Corso, Pascale V, Marrelli D, Roviello F. UVRAG poly-adenine deletions in human gastric cancer. Human Pathology, 43:961-962;2012.
45. Giovanni Corso, Marrelli D, Roviello F. Familial gastric cancer and germline mutations of E-cadherin. Annali Italiani di Chirurgia, 83:1771-82;2012.
46. Giovanni Corso, Seruca R, Roviello F. Gastric cancer carcinogenesis and tumor progression. Annali Italiani di Chirurgia, 83:172-176;2012.
47. Dulak AM, Schumacher S, van Lieshout J, Imamura Y, Fox C, Shim B, Ramos A, Saksena G, Baca S, Baselga J, Tabernero J, Barretina J, Enzinger P, Giovanni Corso, Roviello F, Lin L, Bandla S, Luketich J, Pennathur A, Meyerson M, Ogino S, Shivdasani RA, Beer DG, Godfrey TE, Beroukhim R, Bass AJ. Gastrointestinal adenocarcinomas of the esophagus, stomach and colon exhibit distinct patterns of genome instability and oncogenesis. Cancer Research, 72:4383-4393, 2012.
48. Giovanni Corso, Joana Carvalho, Marrelli D, Vindigni C, Carvalho B, Seruca R, Roviello F, Oliveira C. Somatic mutations and deletions of the E-cadherin gene predict poor survival of gastric cancer patients independently of the histologic type. Journal of Clinical Oncology, 31:868-875, 2013.
49. Neri A, Lambert Y, Marrelli D, Di Mare G, Mastrogiacomo D, Giovanni Corso G, Volterrani L, Roviello F. Gastro-pleuro-pericardial fistula following combined radiation and chemotherapy for lung metastases from renal cell carcinoma: report of a case. Surgery Today, 2013 in press.
50. Giovanni Corso, Roncalli F, Marrelli D, Carneiro F, Roviello F. History, Pathogenesis, and Management of Familial Gastric Cancer: Original Study of John XXIII's Family. Biomedicine Research International 2013;2013:385132.
51. Giovanni Corso, Pascale V, Ferrara F, Flauti G, Marrelli D, Roviello F. Oncogenic mutations with microsatellite instability phenotype predict specific anatomical subsite in colorectal cancer patients. European Journal of Human Genetics, 2013 in press

BOOKS

1. Giovanni Corso, D. Marrelli, F. Roviello. Etiopathogenesis of Gastric Cancer. Surgery in the Multimodal Management of Gastric Cancer. Cap. 2; Springer-Verlag 2011.
2. F. Roviello, Giovanni Corso, D. Marrelli. Long-Term Results after R0 Resection in the Surgical Treatment of Gastric Cancer. Surgery in the Multimodal Management of Gastric Cancer. Cap. 17; Springer-Verlag 2011.
3. F. Roviello, Giovanni Corso, D. Marrelli. Standard and Extended Lymphadenectomy: Technical Notes. Surgery in the Multimodal Management of Gastric Cancer. Cap 33; Springer-Verlag 2011.
4. Giovanni Corso and Roviello F. Editor and author of “Spotlight on familial and Hereditary gastric cancer” book; Springer Edition 2013
e-mail:giovanni.corso@ieo.eu
Address:University of Gothenburg
SE - Sweden

Last update: Tuesday, November 26, 2013
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